反应详情

温度

80 °C

5-bromo-N-methyl-2-nitroaniline (1.5 g) was dissolved in methanol (60 mL) by heating to 80° C. Hydrazine hydrate was added (3.2 mL) followed by Raney Nickel (50% slurry in water, 6 drops) and the reaction mixture was heated to reflux for 1 hour. The reaction mixture was filtered through Celite® and concentrated under reduced pressure, providing 5-bromo-N1-methylbenzene-1,2-diamine as an amber oil. This product was used in the next step without further purification.

1. temperaturethe reaction mixture was heated
2. temperatureto reflux for 1 hour
3. filtrationThe reaction mixture was filtered through Celite®
4. concentrationconcentrated under reduced pressure