4-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione → HCID 45380988, compound

HRID 1402791Notes

Reaction equation

HRID 1402791 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH2:9])=[C:5]([NH2:10])[CH:4]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH:18]2[CH2:24][C:23](=O)[O:22][C:20](=[O:21])[CH2:19]2)=[CH:14][CH:13]=1>>[Cl:11][C:12]1[CH:13]=[CH:14][C:15]([CH:18]([CH2:24][C:23]2[NH:10][C:5]3[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=3[N:9]=2)[CH2:19][C:20]([OH:22])=[O:21])=[CH:16][CH:17]=1.[ClH:11]

Participants

3

Reactant 2

HCID 1046394-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dioneHCID 1534044-Methoxy-o-phenylenediamine

Product 1

HCID 45380988HCID 45380988, compound

Procedure

By a procedure similar to that of example 1.4, starting from commercial 4-methoxy-1,2-phenylenediamine and 3-(4-chlorophenyl)glutaric anhydride, 3-(4-chlorophenyl)-4-(5-methoxy-2-benzimidazolyl)butanoic acid•HCl was obtained as light red solid, provided that cyclisation of the crude glutaramic acid was carried out with HCl in 1,4-dioxane at reflux for 1.5 h.

Sources & evidence

ORD record
ord-bb43f73478f245a980add1016b1d23c5
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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