Hydrochloric Acid → HCID 66760082, compound

Participants

Reaction Steps

The solution of ethyl 4-(5,6-dichloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoate (0.31 g) in a mixture of acetic acid (2 ml) and conc. HCl (0.5 ml) was heated to reflux for 1 h. Then all volatiles are removed at the water aspirator. The residue is dried by distillation with toluene (50 ml) and triturated with boiling acetone (5 ml). The precipitate is collected by filtration, washed with acetone and dried in vacuo to yield 4-(5,6-dichloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid•HCl (0.26 g) as colourless solid.

Provenance & Evidence