Hydrochloric Acid → HCID 66760082, compound

HRID 1402799Notes

Reaction equation

HRID 1402799 reaction equation
[Cl:1][C:2]1[C:25]([Cl:26])=[CH:24][C:5]2[N:6]=[C:7]([CH2:9][CH:10]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[CH2:11][C:12]([O:14]CC)=[O:13])[NH:8][C:4]=2[CH:3]=1.[ClH:27]>C(O)(=O)C>[Cl:26][C:25]1[C:2]([Cl:1])=[CH:3][C:4]2[N:8]=[C:7]([CH2:9][CH:10]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[CH2:11][C:12]([OH:14])=[O:13])[NH:6][C:5]=2[CH:24]=1.[ClH:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66760143HCID 66760143, compound

Product 1

HCID 66760082HCID 66760082, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The solution of ethyl 4-(5,6-dichloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoate (0.31 g) in a mixture of acetic acid (2 ml) and conc. HCl (0.5 ml) was heated to reflux for 1 h. Then all volatiles are removed at the water aspirator. The residue is dried by distillation with toluene (50 ml) and triturated with boiling acetone (5 ml). The precipitate is collected by filtration, washed with acetone and dried in vacuo to yield 4-(5,6-dichloro-2-benzimidazolyl)-3-(4-chlorophenyl)butanoic acid•HCl (0.26 g) as colourless solid.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 1 h
  3. customThen all volatiles are removed at the water
  4. dry with materialThe residue is dried by distillation with toluene (50 ml)
  5. customtriturated with boiling acetone (5 ml)
  6. filtrationThe precipitate is collected by filtration
  7. washwashed with acetone
  8. customdried in vacuo

Sources & evidence

ORD record
ord-71bdb259387d4ecd9c0db043beae4fd9
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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