2-Amino-4-chlorophenol → HCID 66759860, compound

HRID 1402834Notes

Reaction equation

HRID 1402834 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:14][C:13](=[O:15])[O:12][C:10](=[O:11])[CH2:9]2)=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([OH:24])=[C:21]([CH:23]=1)[NH2:22]>ClCCl>[OH:24][C:20]1[CH:19]=[CH:18][C:17]([Cl:16])=[CH:23][C:21]=1[NH:22][C:13](=[O:15])[CH2:14][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:9][C:10]([OH:12])=[O:11]

Participants

4

Reactant 2

HCID 72652-Amino-4-chlorophenolHCID 1046394-(4-Chlorophenyl)dihydro-2H-pyran-2,6(3H)-dione

Product 1

HCID 66759860HCID 66759860, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Prepared by dissolving an equimolar mixture of 3-(4-chlorophenyl)glutaric anhydride and commercial 5-chloro-2-hydroxyaniline in boiling dichloromethane. Upon cooling to rt product precipitates and yields after isolation 87% of N-(2-hydroxy-5-chlorophenyl)-3-(4-chlorophenyl)glutaramic acid as colourless crystals.

Workup

  1. customPrepared
  2. dissolutionby dissolving
  3. customprecipitates

Sources & evidence

ORD record
ord-da910cfc6c474ddea5f90e353b664b7c
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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