HCID 66759828, compound → HCID 12635770, compound

HRID 1402848Notes

Reaction equation

HRID 1402848 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:24])[CH2:9][CH:10]([CH:17](C(O)=O)[C:18]([OH:20])=[O:19])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1>CC(C)=O.CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:24])[CH2:9][CH:10]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:17][C:18]([OH:20])=[O:19])=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 66759828HCID 66759828, compound

Product 1

HCID 12635770HCID 12635770, compoundYield 72.5%

Reagents, catalysts & solvents 1

HCID 21894497Aceton-methanolSolvent

Procedure

Neat 2-[3-(4-chlorophenyl)-3-oxo-1-phenylpropyl]malonic acid (0.3 g) was heated to 160° C. with stirring for 1 h. After cooling to rt the crude was dissolved in acetone/methanol. Precipitation of product was effected by addition of dichloromethane. The precipitate was collected to afford 5-(4-chlorophenyl)-5-oxo-3-phenylpentanoic acid (0.19 g) as colourless crystals.

Workup

  1. customPrecipitation of product
  2. additionwas effected by addition of dichloromethane
  3. customThe precipitate was collected

Sources & evidence

ORD record
ord-42511c1199214d8ca6c63a658bebdee6
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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