Diethyl Malonate → HCID 66759005, compound

HRID 1402852Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([C:12]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][CH:13]=2)=[O:11])=[CH:4][CH:3]=1.[C:19]([O:27][CH2:28][CH3:29])(=[O:26])[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:19]([O:27][CH2:28][CH3:29])=[O:26])[CH2:9][C:10]([C:12]2[CH:13]=[CH:14][C:15]([I:18])=[CH:16][CH:17]=2)=[O:11])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7761Diethyl Malonate

HCID 4394391HCID 4394391, compound

Product 1

HCID 66759005HCID 66759005, compound

Procedure

By a procedure similar to that of example 1.59.2, starting from 3-(4-chlorophenyl)-1-(4-iodophenyl)prop-2-en-1-one and diethyl malonate, diethyl 2-(1-(4-chlorophenyl)-3-(4-iodophenyl)-3-oxopropyl)malonate was obtained as beige coloured solid.

Sources & evidence

ORD record: ord-9f3597358def49a98635d764882ff92a
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912186B2

Reaction notes

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