Diethyl Malonate → HCID 66760105, compound

HRID 1402854Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:17])[CH:9]=[CH:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:4][CH:3]=1.[C:18]([O:26][CH2:27][CH3:28])(=[O:25])[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](=[O:17])[CH2:9][CH:10]([CH:19]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:18]([O:26][CH2:27][CH3:28])=[O:25])[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 7761Diethyl Malonate

HCID 97699HCID 97699, compound

Product 1

HCID 66760105HCID 66760105, compound

Procedure

By a procedure similar to that of example 1.59.2, starting from 1-(4-bromophenyl)-3-phenylprop-2-en-1-one and diethyl malonate, diethyl 2-[3-(4-bromophenyl)-3-oxo-1-phenylpropyl]malonate was obtained as colourless solid.

Sources & evidence

ORD record: ord-b676c196f6e4466d869cec12dd096de3
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912186B2

Reaction notes

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