Diethyl Malonate → Diethyl 2-[3-(4-ethylphenyl)-3-oxo-1-phenylpropyl]malonate

HRID 1402858Notes

Reaction equation

HRID 1402858 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:18])[CH:10]=[CH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][CH:4]=1)[CH3:2].[C:19]([O:27][CH2:28][CH3:29])(=[O:26])[CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:18])[CH2:10][CH:11]([CH:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:19]([O:27][CH2:28][CH3:29])=[O:26])[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 7761Diethyl MalonateHCID 667593291-(4-Ethylphenyl)-3-phenylprop-2-en-1-one

Product 1

HCID 66759689Diethyl 2-[3-(4-ethylphenyl)-3-oxo-1-phenylpropyl]malonate

Procedure

By a procedure similar to that of example 1.59.2, starting from 1-(4-ethylphenyl)-3-phenylprop-2-en-1-one and diethyl malonate, diethyl 2-[3-(4-ethylphenyl)-3-oxo-1-phenylpropyl]malonate was obtained as colourless solid.

Sources & evidence

ORD record
ord-68243d6d037042dfbb2e1b6a180550e3
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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