Diethyl Malonate → HCID 66759501, compound

HRID 1402871Notes

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10](=[O:19])[CH:11]=[CH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:2]1.[C:20]([O:28][CH2:29][CH3:30])(=[O:27])[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10](=[O:19])[CH2:11][CH:12]([CH:21]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[C:20]([O:28][CH2:29][CH3:30])=[O:27])[C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[CH:2]1

Participants

Reactant 2

HCID 7761Diethyl Malonate

HCID 2368096937-38-8

Product 1

HCID 66759501HCID 66759501, compound

Procedure

By a procedure similar to that of example 1.59.2, starting from 1-(1H-indol-3-yl)-3-phenylprop-2-en-1-one and diethyl malonate, diethyl 2-[3-(1H-indol-3-yl)-3-oxo-1-phenylpropyl]malonate was obtained as yellowish solid.

Sources & evidence

ORD record: ord-96d0af766a7f4db8a19c56de4796b62b
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912186B2

Reaction notes

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