1-(4-(Trifluoromethyl)phenyl)ethan-1-one → 3-(4-Phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

HRID 1402951Notes

Reaction equation

HRID 1402951 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([CH:12]=O)[S:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:14][C:15]([F:26])([F:25])[C:16]1[CH:21]=[CH:20][C:19]([C:22](=[O:24])[CH3:23])=[CH:18][CH:17]=1>>[C:1]1([C:7]2[CH:8]=[C:9]([CH:12]=[CH:23][C:22]([C:19]3[CH:20]=[CH:21][C:16]([C:15]([F:14])([F:25])[F:26])=[CH:17][CH:18]=3)=[O:24])[S:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 697311-(4-(Trifluoromethyl)phenyl)ethan-1-oneHCID 50094674-Phenylthiophene-2-carbaldehyde

Product 1

HCID 667593943-(4-Phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one

Procedure

By a procedure similar to that of example 1.59.1, starting from 4-phenylthiophene-2-carbaldehyde and p-(trifluoromethyl)acetophenone, 3-(4-phenylthiophen-2-yl)-1-(4-(trifluoromethyl)phenyl)prop-2-en-1-one was obtained as yellow solid.

Sources & evidence

ORD record
ord-a9d0e634f97b424d9a84369c56a7651f
Source dataset
uspto-grants-2014_12
Patent number
US08912186B2

Reaction notes

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