1-Methylpiperazine → HCID 46901757, compound

HRID 1402995Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl[C:9]1[N:14]=[C:13]2[N:15]=[CH:16][CH:17]=[C:18]([O:19][C:20]3[CH:25]=[CH:24][C:23]([NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30])=[C:22]([F:34])[CH:21]=3)[C:12]2=[N:11][CH:10]=1>>[F:34][C:22]1[CH:21]=[C:20]([O:19][C:18]2[C:12]3=[N:11][CH:10]=[C:9]([N:5]4[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]4)[N:14]=[C:13]3[N:15]=[CH:16][CH:17]=2)[CH:25]=[CH:24][C:23]=1[NH:26][C:27](=[O:33])[O:28][C:29]([CH3:32])([CH3:31])[CH3:30]

Participants

Reactant 2

HCID 531671-Methylpiperazine

HCID 46899947HCID 46899947, compound

Product 1

HCID 46901757HCID 46901757, compound

Procedure

Method D6 was used with N-methylpiperazine and tert-butyl 4-(3-chloropyrido[2,3-b]pyrazin-8-yloxy)-2-fluorophenylcarbamate to give the title compound as a yellow solid. Yield: 142 mg (92%).

Sources & evidence

ORD record: ord-fec524a0a5954720bfbad16e655a0255
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912191B2

Reaction notes

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