Hydrochloric Acid → 2-(3-Tert-butyl-5-carboxy-1H-pyrazol-1-yl)-N,N-dimethylethanaminium chloride

HRID 1403071Notes

Reaction equation

HRID 1403071 reaction equation
[C:1]([C:5]1[CH:9]=[C:8]([C:10]([O:12]CC)=[O:11])[N:7]([CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])[N:6]=1)([CH3:4])([CH3:3])[CH3:2].[ClH:20]>>[Cl-:20].[C:1]([C:5]1[CH:9]=[C:8]([C:10]([OH:12])=[O:11])[N:7]([CH2:15][CH2:16][NH+:17]([CH3:19])[CH3:18])[N:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 59588870ethyl 3-tert-butyl-1-(2-(dimethylamino)ethyl)-1H-pyrazole-5-carboxylate

Product 1

HCID 687737762-(3-Tert-butyl-5-carboxy-1H-pyrazol-1-yl)-N,N-dimethylethanaminium chloride

Conditions

Temperature
80 °C

Procedure

Ethyl 3-tert-butyl-1-(2-(dimethylamino)ethyl)-1H-pyrazole-5-carboxylate (98 mg, 0.367 mmol) was dissolved in 6M aqueous HCl (4 mL, 24.00 mmol) and the colorless solution was heated to 80° C. for 72 h. The volatiles were evaporated in vacuo and the resulting white solid was coevaporated with Et2O 10 mL) to give the title compound as a white solid. Yield: 100 mg (99%).

Workup

  1. customThe volatiles were evaporated in vacuo

Sources & evidence

ORD record
ord-7da2dff5680149fba1b37ef1d12c8941
Source dataset
uspto-grants-2014_12
Patent number
US08912191B2

Reaction notes

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