反应详情

trans-N,N-Dibenzyl-4-[3-(pyrrolidin-1-yl)propoxy]cyclohexanamine (115 mg) was dissolved in ethanol (2.3 ml), and 20% palladium hydroxide/carbon 50% wet (20 mg) was added thereto, followed by catalytic reduction at room temperature for 4 hours at 3 atm under a hydrogen atmosphere. The catalyst was removed by filtration after nitrogen substitution, and then concentrated under reduced pressure to obtain trans-4-[3-(pyrrolidin-1-yl)propoxy]cyclohexanamine (48 mg).

1. customThe catalyst was removed by filtration after nitrogen substitution
2. concentrationconcentrated under reduced pressure