反应详情

3-Methoxy-4-trimethylsilanylethynyl-phenylamine (1.86 g, 8.45 mmol) in MeOH (17 mL) was treated with solid K2CO3 (1.17 g, 8.45 mmol). After stirring at room temperature the volatiles were removed by evaporation, the residue was taken up with EtOAc (50 mL), washed with water (50 mL), brine, dried over sodium sulfate and evaporated. The crude was purified by flash chromatography on silica gel (heptane/EtOAc 65/35) to afford 520 mg of title compound (42% yield).

1. customwere removed by evaporation
2. washwashed with water (50 mL), brine
3. dry with materialdried over sodium sulfate
4. customevaporated
5. customThe crude was purified by flash chromatography on silica gel (heptane/EtOAc 65/35)