反应详情

To a solution of methyl 4-chloro-2-hydroxybenzoate (21 g, 112.55 mmol) in acetone (200 mL) was added ethyl 2-bromoacetate (28.3 g, 169.46 mmol) and potassium carbonate (23.4 g, 169.31 mmol). After refluxing for 3 h, the solids were collected by filtration. The resulting mixture was concentrated under vacuum, dissolved in petroleum ether (300 mL) and filtered to give methyl 4-chloro-2-(2-ethoxy-2-oxoethoxy)benzoate as a red solid (26 g, 85%).

1. temperatureAfter refluxing for 3 h
2. filtrationthe solids were collected by filtration
3. concentrationThe resulting mixture was concentrated under vacuum
4. dissolutiondissolved in petroleum ether (300 mL)
5. filtrationfiltered