HCID 13013041, compound → 6-Methyl-1-benzofuran-3(2H)-one

HRID 1403374Notes

Reaction equation

HRID 1403374 reaction equation
C([O:4][C:5]1[C:9]2[CH:10]=[CH:11][C:12]([CH3:14])=[CH:13][C:8]=2[O:7][CH:6]=1)(=O)C>Cl.CO.O>[CH3:14][C:12]1[CH:11]=[CH:10][C:9]2[C:5](=[O:4])[CH2:6][O:7][C:8]=2[CH:13]=1

Participants

5

Reactant 1

HCID 13013041HCID 13013041, compound

Product 1

HCID 303496-Methyl-1-benzofuran-3(2H)-oneYield 84.5%

Reagents, catalysts & solvents 3

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

A solution of 6-methyl-1-benzofuran-3-yl acetate (3.8 g, 19.98 mmol) in HCl (4 mL, conc), methanol (160 mL), and water (40 mL) was heated under reflux for 1.5 h, the reaction mixture was cooled to room temperature, dissolved in water (200 mL) and filtered to give 6-methyl-2,3-dihydro-1-benzofuran-3-one as a white solid (2.5 g, 82%).

Workup

  1. temperatureunder reflux for 1.5 h
  2. filtrationfiltered

Sources & evidence

ORD record
ord-75f79bb0ab40469d8f7456c064634fd3
Source dataset
uspto-grants-2014_12
Patent number
US08912188B2

Reaction notes

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