反应详情

温度

90 °C

To a solution of phenylboronic acid (15 g, 123.02 mmol) in dioxane (150.0 mL) and water (3.0 mL) was added 3-bromofuran (16.3 g, 110.91 mmol), K3PO4 (43 g, 202.57 mmol) and Pd(PPh3)4 (6.0 g, 5.19 mmol) with stirring for 2 h at 90° C. in an oil bath maintained with an inert atmosphere of nitrogen. The reaction mixture was concentrated under reduced pressure to give the residue, which was purified by silica gel column chromatography eluting with 1% ethyl acetate in petroleum ether to afford 3-phenylfuran as a white solid (15 g, 85%).

1. temperaturemaintained with an inert atmosphere of nitrogen
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. customto give the residue, which
4. customwas purified by silica gel column chromatography
5. washeluting with 1% ethyl acetate in petroleum ether