反应详情

温度

0 °C

To a solution of (S)-methyl 3-(2-methylpyrrolidin-1-yl)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (200 mg, 0.70 mmol) in dichloromethane (30 mL) was added pyridine (220 mg, 2.78 mmol) and then Tf2O (393 mg, 1.39 mmol) was added dropwise with stirring at 0° C. The resulting solution was stirred overnight at room temperature and then quenched by the addition of ice-water (20 mL), extracted with dichloromethane (3×20 mL), dried over anhydrous sodium sulfate and concentrated in vacuo to afford (S)-methyl 3-(2-methylpyrrolidin-1-yl)-2-(trifluoromethylsulfonyloxy)quinoxaline-6-carboxylate as red oil (300 mg, crude).

1. stirringThe resulting solution was stirred overnight at room temperature
2. customquenched by the addition of ice-water (20 mL)
3. extractionextracted with dichloromethane (3×20 mL)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated in vacuo