Hydrochloric Acid → HCID 60198476, compound

HRID 1403419Notes

Reaction equation

HRID 1403419 reaction equation
[CH:1]([N:4]([CH3:29])[C:5]1[C:6]([C:19]2[CH:28]=[C:27]3[C:22]([N:23]=[CH:24][CH:25]=[N:26]3)=[CH:21][CH:20]=2)=[N:7][C:8]2[C:13]([N:14]=1)=[CH:12][C:11]([C:15]([O:17]C)=[O:16])=[CH:10][CH:9]=2)([CH3:3])[CH3:2].[OH-].[Na+].Cl>CO.O>[CH:1]([N:4]([CH3:29])[C:5]1[C:6]([C:19]2[CH:28]=[C:27]3[C:22]([N:23]=[CH:24][CH:25]=[N:26]3)=[CH:21][CH:20]=2)=[N:7][C:8]2[C:13]([N:14]=1)=[CH:12][C:11]([C:15]([OH:17])=[O:16])=[CH:10][CH:9]=2)([CH3:3])[CH3:2]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 70664655HCID 70664655, compound

Product 1

HCID 60198476HCID 60198476, compoundYield 50.8%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

To a solution of methyl 3-(isopropyl(methyl)amino)-2,7′-biquinoxaline-6-carboxylate (90 mg, 0.23 mmol) in methanol (30 mL) and water (1 ml), was added sodium hydroxide (54 mg, 1.35 mmol). After stirring overnight at room temperature, the reaction mixture was concentrated under reduced pressure to afford a residue, which was dissolved in water (10 ml), adjusted the pH value to 6 with HCl (3N) and filtered to give 3-(isopropyl(methyl)amino)-2,7′-biquinoxaline-6-carboxylic acid as a light yellow solid (43.6 mg, 50%).

Workup

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customto afford a residue, which
  3. filtrationfiltered

Sources & evidence

ORD record
ord-8289835ec70a4f9cb1752830e8ec9e3e
Source dataset
uspto-grants-2014_12
Patent number
US08912188B2

Reaction notes

Loading…