反应详情

To a solution of methyl 3-(cyclopropyl(methyl)amino)-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (120 mg, 0.44 mmol) in dichloromethane (10 mL) was added pyridine (139 mg, 1.76 mmol) and Tf2O (248 mg, 0.88 mmol) under a nitrogen atmosphere. After stirring overnight at room temperature, the reaction was quenched by the addition water/ice (50 mL), extracted with dichloromethane (2×10 mL), dried over anhydrous magnesium sulfate and concentrated in vacuo to give methyl 3-(cyclopropyl(methyl)amino)-2-(trifluoromethylsulfonyloxy)quinoxaline-6-carboxylate as red oil (150 mg, crude).

1. customthe reaction was quenched by the addition water/ice (50 mL)
2. extractionextracted with dichloromethane (2×10 mL)
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationconcentrated in vacuo