反应详情

The solution of methyl 5-amino-2-fluoro-4-(4-methoxybenzylamino)benzoate (30 g, 98.58 mmol) in diethyl oxalate (100 ml) was stirred for 3 h at reflux and then cooled with a water/ice bath, diluted with ether (500 ml). The product was collected by filtration to afford methyl 7-fluoro-1-(4-methoxybenzyl)-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate as a light yellow solid (35.0 g, 99%).

1. temperatureat reflux
2. temperaturecooled with a water/ice bath
3. filtrationThe product was collected by filtration