反应详情

温度

85 °C

To a solution of methyl 3-chloro-7-fluoro-2-oxo-1,2-dihydroquinoxaline-6-carboxylate (2.0 g, crude) in DMSO (20 ml) was added DIEA (2.0 g, 15.48 mmol) and methyl(propan-2-yl)amine (790 mg, 10.80 mmol) with stirring at 85° C. overnight. The reaction mixture was cooled to room temperature. The product was precipitated by the addition water and the solids were collected by filtration to afford methyl 7-fluoro-3-[methyl(propan-2-yl)amino]-2-oxo-1,2-dihydroquinoxaline-6-carboxylate as a light yellow solid (800 mg).

1. temperatureThe reaction mixture was cooled to room temperature
2. customThe product was precipitated by the addition water
3. filtrationthe solids were collected by filtration