4-Bromoaniline → 4'-Bromoacetanilide

HRID 1403660Notes

Reaction equation

HRID 1403660 reaction equation
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:9](=[O:11])[CH3:10])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 78074-BromoanilineHCID 7918Acetic Anhydride

Product 1

HCID 76834'-BromoacetanilideYield 96%

Procedure

A solution of 4-bromoaniline (10 g, 58.13 mmol) in acetic anhydride (50 mL) was stirred for 20 minutes at room temperature, and then collected by filtration to give N-(4-bromophenyl)acetamide (12 g, 96%) as a white solid.

Workup

  1. filtrationcollected by filtration

Sources & evidence

ORD record
ord-f7a07405815746b3bde2f6921c9ec64a
Source dataset
uspto-grants-2014_12
Patent number
US08912188B2

Reaction notes

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