Trifluoroacetic acid → HCID 71546516, compound

HRID 1403700Notes

Reaction equation

HRID 1403700 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]1[C:21]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:27]=3[C:28](=[O:29])[C:20]=2[C:19]2[C:14](=[CH:15][C:16]([NH:30][C:31](=[O:36])[C:32]([O:34][CH3:35])=[O:33])=[CH:17][CH:18]=2)[C:13]1=[O:37])=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)(Cl)Cl>[NH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:21]2[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:27]=3[C:28](=[O:29])[C:20]=2[C:19]2[C:14](=[CH:15][C:16]([NH:30][C:31](=[O:36])[C:32]([O:34][CH3:35])=[O:33])=[CH:17][CH:18]=2)[C:13]1=[O:37]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 71546349HCID 71546349, compound

Product 1

HCID 71546516HCID 71546516, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Compound 17 (0.070 g, 0.130 mmol) was treated with trifluoroacetic acid (0.5 mL) in chloroform (5 mL) for 2 h at room temperature. The solvent was removed on a rotary evaporator and the residue was then basified with 2 N NH3 in methanol to get the free amine, which was purified by silica gel column chromatography, eluting with chloroform-methanol, 8.7:1.3, to yield the product 22 (0.035 g, 65%) as a brown solid: mp 185-186° C. IR (KBr) 3014, 1692, 1581, 1570, 1533, 1307, 1198, 722, 455 cm−1; 1H NMR (CD3OD, 300 MHz) δ 8.55 (s, 1 H), 8.23 (d, J=3.2 Hz, 1 H), 7.71 (d, J=3.5 Hz, 1 H), 7.54 (m, 1H), 7.36 (m, 3 H), 4.52 (m, 2 H), 3.91 (s, 3 H), 3.05 (m, 2 H), 2.28 (m, 2 H); 13C NMR (CD3OD, 125 MHz) δ 191.6, 169.9, 166.8, 164.9, 155.4, 138.8, 137.9, 135.7, 134.9, 132.2, 129.6, 127.2, 125.0, 124.8, 124.1, 123.9, 118.6, 109.6, 52.9, 42.5, 38.2, 28.6; ESIMS m/z (relative intensity) 420 (MH+, 100); HRESIMS calcd for C23H21N3O5 420.1559 (MH+), found 420.1554 (MH+); HPLC purity: 98.2% (1% TFA in MeOH).

Workup

  1. customThe solvent was removed on a rotary evaporator

Sources & evidence

ORD record
ord-d9c04321f0354c37bf71a403d93eb7bb
Source dataset
uspto-grants-2014_12
Patent number
US08912213B2

Reaction notes

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