Hydrochloric Acid → HCID 90409894, compound

HRID 1403727Notes

Reaction equation

HRID 1403727 reaction equation
[O:1]=[S:2]1(=[O:22])[N:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.Cl>CCO>[C:9]1([N:8]2[CH2:7][CH2:6][CH2:5][CH2:4][NH:3][S:2]2(=[O:22])=[O:1])[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 90410761HCID 90410761, compound

Product 1

HCID 90409894HCID 90409894, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of tert-butyl 1,1-dioxo-7-phenyl-1λ6,2,7-thiadiazepane-2-carboxylate (860 mg, 2.64 mmol) in a 4 M solution of HCl in EtOH (30 mL) was stirred at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure to afford 2-phenyl-1λ6,2,7-thiadiazepane-1,1-dione as a yellow oil (500 mg, 85%). LCMS (ESI): m/z=227.2 [M+H]+.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-ab472d6961524428a636dfc3c28047dd
Source dataset
uspto-grants-2014_12
Patent number
US08912219B2

Reaction notes

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