HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3,5-Dichloro-4-(4-chlorobenzoyl)benzyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 4-Chlorobenzoyl chloride | HCID 8501 | — |
| Reactant | t-Butyldimethylsilyl-3,5-dichlorobenzyl ether | HCID 67042253 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 3,5-Dichloro-4-(4-chlorobenzoyl)benzyl alcohol | HCID 2817766 | — |
Reaction Steps
React t-Butyldimethylsilyl-3,5-dichlorobenzyl ether (858.A1) (1 mole) with n-Butyllithium 1.6M solution in hexane followed by 4-Chlorobenzoyl chloride, (1.01 mole), in Tetrahydrofuran, while cold and treat the intermediate with aqueous Hydrochloric acid to give 3,5-dichloro-4-(4-chlorobenzoyl)benzyl alcohol (858.B).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08912223B2 |
| Source dataset | uspto-grants-2014_12 |
| ORD ID | ord-5031da7e5a9841b1b8f085d868aa592e |
| Source note | uspto-grants-2014_12 |