反应详情

To the solution of 8-10 (7.0 g, 21.3 mmol) in anhydrous DMF (20 mL) was added KOH (4.34 g, 78.0 mmol), and MeI (4.55 g, 32.0 mmol) at room temperature. After the mixture was stirred for 1 h, TLC showed that the reaction was completed. The mixture was quenched with water and extracted with ethyl acetate (150 mL×3). The organic layers were combined and concentrated in vacuo. 8-11 (7.2 g, crude) was obtained as yellow oil and used for the next step without further purification.

1. customThe mixture was quenched with water
2. extractionextracted with ethyl acetate (150 mL×3)
3. concentrationconcentrated in vacuo
4. custom8-11 (7.2 g, crude) was obtained as yellow oil
5. customused for the next step without further purification