Potassium Hydroxide → 2-(1-ethyl-6-fluoro-4-hydroxy-1H-indol-3-yl)acetic acid

HRID 1404098Notes

Reaction equation

HRID 1404098 reaction equation
BrC1C(OC)=C(Br)C=C(F)C=1N(C/C=C\C(OCC)=O)C(=O)C.[OH-].[Na+].[OH-].[K+].[CH2:28]([N:30]1[C:38]2[C:33](=[C:34]([OH:40])[CH:35]=[C:36]([F:39])[CH:37]=2)[C:32]([CH2:41][C:42]([O:44]C)=[O:43])=[CH:31]1)[CH3:29]>>[CH2:28]([N:30]1[C:38]2[C:33](=[C:34]([OH:40])[CH:35]=[C:36]([F:39])[CH:37]=2)[C:32]([CH2:41][C:42]([OH:44])=[O:43])=[CH:31]1)[CH3:29]

Participants

5

Reactant 4

HCID 14797Potassium HydroxideHCID 14798Sodium HydroxideHCID 66927140methyl 2-(1-ethyl-6-fluoro-4-hydroxy-1H-indol-3-yl)acetateHCID 86654327(Z)-ethyl 4-(N-(2,4-dibromo-6-fluoro-3-methoxyphenyl)acetamido)but-2-enoate

Product 1

HCID 583039722-(1-ethyl-6-fluoro-4-hydroxy-1H-indol-3-yl)acetic acid

Procedure

Following the procedure used to prepare compound 8-7 (step 8 scheme 8), NaOH was replaced by KOH, compound 11-2 gave compound 11-3.

Sources & evidence

ORD record
ord-e93442d1ae0246aca768a6c27ea7132d
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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