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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1404098Generated: October 30, 2026

Potassium Hydroxide → 2-(1-ethyl-6-fluoro-4-hydroxy-1H-indol-3-yl)acetic acid

https://huagongshe.com/reaction/1404098

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPotassium HydroxideHCID 14797—
ReactantSodium HydroxideHCID 14798—
Reactantmethyl 2-(1-ethyl-6-fluoro-4-hydroxy-1H-indol-3-yl)acetateHCID 66927140—
Reactant(Z)-ethyl 4-(N-(2,4-dibromo-6-fluoro-3-methoxyphenyl)acetamido)but-2-enoateHCID 86654327—
Product2-(1-ethyl-6-fluoro-4-hydroxy-1H-indol-3-yl)acetic acidHCID 58303972—

Reaction Steps

Following the procedure used to prepare compound 8-7 (step 8 scheme 8), NaOH was replaced by KOH, compound 11-2 gave compound 11-3.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08912220B2
Source datasetuspto-grants-2014_12
ORD IDord-e93442d1ae0246aca768a6c27ea7132d
Source noteuspto-grants-2014_12