2-(1-ethyl-6-fluoro-4-hydroxy-1H-indol-3-yl)-1-morpholinoethanone → 1-ethyl-6-fluoro-3-(2-morpholinoethyl)-1H-indol-4-ol

HRID 1404100Notes

Reaction equation

HRID 1404100 reaction equation
C(OC1C(F)=CC=C2C=1C(CCN(C)C)=CN2)C1C=CC=CC=1.[CH2:24]([N:26]1[C:34]2[C:29](=[C:30]([OH:36])[CH:31]=[C:32]([F:35])[CH:33]=2)[C:28]([CH2:37][C:38]([N:40]2[CH2:45][CH2:44][O:43][CH2:42][CH2:41]2)=O)=[CH:27]1)[CH3:25]>>[CH2:24]([N:26]1[C:34]2[CH:33]=[C:32]([F:35])[CH:31]=[C:30]([OH:36])[C:29]=2[C:28]([CH2:37][CH2:38][N:40]2[CH2:45][CH2:44][O:43][CH2:42][CH2:41]2)=[CH:27]1)[CH3:25]

Participants

3

Reactant 2

HCID 583040262-(1-ethyl-6-fluoro-4-hydroxy-1H-indol-3-yl)-1-morpholinoethanoneHCID 669270882-(4-Benzyloxy-5-fluoro-1H-indol-3-yl)-N,N-dimethylethanamine

Product 1

HCID 509961671-ethyl-6-fluoro-3-(2-morpholinoethyl)-1H-indol-4-olYield 27%

Procedure

Following the procedure used to prepare compound 1-7a (step 6 scheme 1), compound 11-4 gave compound 11-5 (41 mg, 27%) as a white solid.

Sources & evidence

ORD record
ord-8fa8d67763204b3689ff946172cf665c
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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