Methanol → HCID 58303961, compound

HRID 1404116Notes

Reaction equation

HRID 1404116 reaction equation
[CH3:1][O:2][C:3](=[O:25])/[CH:4]=[CH:5]/[C:6]1[C:7]([O:23][CH3:24])=[C:8]2[C:12](=[C:13]([F:15])[CH:14]=1)[N:11]([CH2:16][CH3:17])[CH:10]=[C:9]2[CH2:18][C:19]([NH:21][CH3:22])=[O:20].[CH3:26]O>[Pd]>[CH3:22][N:21]([CH3:26])[C:19](=[O:20])[CH2:18][C:9]1[C:8]2[C:12](=[C:13]([F:15])[CH:14]=[C:6]([CH2:5][CH2:4][C:3]([O:2][CH3:1])=[O:25])[C:7]=2[O:23][CH3:24])[N:11]([CH2:16][CH3:17])[CH:10]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 66927214HCID 66927214, compound

Product 1

HCID 58303961HCID 58303961, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

To a solution of 27-1 (200 mg, 0.57 mmol) in 20 mL of MeOH was added 0.1 g of Pd/C (10%). The mixture was stirred over night under H2 atmosphere at room temperature. The mixture was filtered and the filtrate was to afford 27-2 (150 mg, 0.42 mmol, 74%) as a white solid. LRMS: calc 364.1 and found: 365.1 [MH]+.

Workup

  1. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-f6903a26ed89422ea28b496074f05cc5
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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