反应详情

A solution of 29-2 (230 mg, 0.52 mmol) in acetic acid (10 mL) was heated to 80° C. for 3 h. After cooled to room temperature, water (10 mL) and sat. aqueous NaHCO3 (30 mL) were added. The mixture was extracted with ethyl acetate (3×20 mL). The combined organic layer was dried with MgSO4, filtered and evaporated to afford 29-3 (150 mg, 68%) as yellow oil. LRMS: calc 422.5 and found: 423.2 [M+1].

1. extractionThe mixture was extracted with ethyl acetate (3×20 mL)
2. dry with materialThe combined organic layer was dried with MgSO4
3. filtrationfiltered
4. customevaporated