Acetic Anhydride → HCID 58304027, compound

HRID 1404125Notes

Reaction equation

HRID 1404125 reaction equation
[Br:1][C:2]1[C:7]([O:8][CH2:9][CH3:10])=[C:6]([F:11])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH2:13].[C:14](OC(=O)C)(=[O:16])[CH3:15]>>[Br:1][C:2]1[C:7]([O:8][CH2:9][CH3:10])=[C:6]([F:11])[CH:5]=[C:4]([Cl:12])[C:3]=1[NH:13][C:14](=[O:16])[CH3:15]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 58303855HCID 58303855, compound

Product 1

HCID 58304027HCID 58304027, compoundYield 76%

Procedure

A solution of 30-5 (16 g, 59.7 mmol) in acetic anhydride (50 mL) was stirred at room temperature for one hour. The precipitate was filtered and washed with ether to afford 30-6 (14 g, 76%) as a white solid. LRMS: calc 308.9 and found: 309.9 [M+1].

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with ether

Sources & evidence

ORD record
ord-ce3271f7991d4a5b916cdb55d7111f39
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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