6-bromo-1-ethyl-4-methoxy-1H-indole → 2-(6-bromo-1-ethyl-4-methoxy-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide

HRID 1404144Notes

Reaction equation

HRID 1404144 reaction equation
C(OC1C(F)=CC=C2C=1C([C:19](=[O:25])[C:20]([N:22]([CH3:24])[CH3:23])=[O:21])=CN2)C1C=CC=CC=1.[Br:26][C:27]1[CH:35]=[C:34]2[C:30]([CH:31]=[CH:32][N:33]2[CH2:36][CH3:37])=[C:29]([O:38][CH3:39])[CH:28]=1>>[Br:26][C:27]1[CH:35]=[C:34]2[C:30]([C:31]([C:19](=[O:25])[C:20]([N:22]([CH3:24])[CH3:23])=[O:21])=[CH:32][N:33]2[CH2:36][CH3:37])=[C:29]([O:38][CH3:39])[CH:28]=1

Participants

3

Reactant 2

HCID 583039096-bromo-1-ethyl-4-methoxy-1H-indoleHCID 669271792-(4-Benzyloxy-5-fluoro-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide

Product 1

HCID 583039862-(6-bromo-1-ethyl-4-methoxy-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamideYield 88%

Procedure

Following the procedure (step 5, scheme 1) used to prepare compound 1-6a, compound 36-2 gave compound 36-3 (669 mg, 88%) as a pale pink solid. LCMS: calc 352.0 and found: 353.0 [MH]+.

Sources & evidence

ORD record
ord-28c5eae5db254bf6b3a2f6169226b76b
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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