1-ethyl-6-fluoro-3-(2-(isoindolin-2-yl)ethyl)-1H-indol-4-ol → 1-ethyl-6-fluoro-3-(2-hydroxyethyl)-1H-indol-4-ol

HRID 1404151Notes

Reaction equation

HRID 1404151 reaction equation
C(N1C2C=C(F)C=C(O)C=2C(CCN2CC3C(=CC=CC=3)C2)=C1)C.C([O:32][C:33]1[CH:41]=[C:40]([F:42])[CH:39]=[C:38]2[C:34]=1[C:35]([CH2:45][CH2:46][OH:47])=[CH:36][N:37]2[CH2:43][CH3:44])C1C=CC=CC=1>>[CH2:43]([N:37]1[C:38]2[CH:39]=[C:40]([F:42])[CH:41]=[C:33]([OH:32])[C:34]=2[C:35]([CH2:45][CH2:46][OH:47])=[CH:36]1)[CH3:44]

Participants

3

Reactant 2

HCID 509963501-ethyl-6-fluoro-3-(2-(isoindolin-2-yl)ethyl)-1H-indol-4-olHCID 583039622-(4-(Benzyloxy)-1-ethyl-6-fluoro-1H-indol-3-yl)ethanol

Product 1

HCID 669272011-ethyl-6-fluoro-3-(2-hydroxyethyl)-1H-indol-4-olYield 99%

Procedure

Following the procedure (step 3 scheme 31 used to prepare compound 31-4 compound 26-5 gave compound 39-2 (318 mg, 99%) as a light purple solid.

Sources & evidence

ORD record
ord-0b72e20f982847deb0a90c5536168a01
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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