2-(7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-9-yl)acetic acid → 2-(7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-9-yl)acetamide

HRID 1404156Notes

Reaction equation

HRID 1404156 reaction equation
C(OC1C=C(F)C=C2C=1C(CC(N1CC3C(=CC=CC=3)C1)=O)=C[N:13]2CC)C1C=CC=CC=1.[CH2:33]([N:36]1[C:44]2[C:39](=[C:40]3[O:48][CH2:47][CH2:46][O:45][C:41]3=[CH:42][CH:43]=2)[C:38]([CH2:49][C:50]([OH:52])=O)=[CH:37]1)[CH2:34][CH3:35]>>[CH2:33]([N:36]1[C:44]2[C:39](=[C:40]3[O:48][CH2:47][CH2:46][O:45][C:41]3=[CH:42][CH:43]=2)[C:38]([CH2:49][C:50]([NH2:13])=[O:52])=[CH:37]1)[CH2:34][CH3:35]

Participants

3

Reactant 2

HCID 669271902-(7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-9-yl)acetic acidHCID 672350282-(4-(benzyloxy)-1-ethyl-6-fluoro-1H-indol-3-yl)-1-(isoindolin-2-yl)ethanone

Product 1

HCID 669272262-(7-propyl-3,7-dihydro-2H-[1,4]dioxino[2,3-e]indol-9-yl)acetamideYield 100%

Procedure

Following the procedure (step 1, scheme 31) used to prepare compound 31-2, compound 40-5 gave compound 40-6 in 100% yield as yellow oil. LCMS: calc 274.1 found 275.0 [MH]+.

Sources & evidence

ORD record
ord-bfd21bb846554d219a96d17ea1613b8b
Source dataset
uspto-grants-2014_12
Patent number
US08912220B2

Reaction notes

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