HRID1404349

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID81531

Diisopropylethylamine

C8H19N

HCID12801779

Propan-2-yl methanimidate--hydrogen chloride (1/1)

C4H10ClNO

反应SMILES：NCCN[C@H]1CC[C@H](CC(=O)N[C@H]2Cc3cccc(C(=O)O)c3OB2O)CC1

HCID178511351

未命名化合物

PRODUCTS

产物

反应SMILES：O=C(C[C@H]1CC[C@H](N2C=NCC2)CC1)N[C@H]1Cc2cccc(C(=O)O)c2OB1O

HCID178520737

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid (Example 15) in MeOH was added DIEA (2.5 eq), followed by isopropyl formimidate hydrochloride (1.2 eq). The reaction mixture was stirred at RT overnight. The mixture was then concentrated in vacuo and the crude product was purified using reverse phase HPLC to afford the title compound. ESI-MS m/z 400 (MH)+.

WORKUP

后处理

concentrationThe mixture was then concentrated in vacuo
customthe crude product was purified