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HRID1404352

反应详情

EQUATION

反应方程式

HRID 1404352 的结构方程式

REACTANTS

反应物

2
反应SMILES：CC(C)(C)OC(=O)N1CCC(C=O)CC1
HCID1514430

tert-Butyl 4-formylpiperidine-1-carboxylate

C11H19NO3

反应SMILES：N[C@H]1CC[C@H](CC(=O)N[C@H]2Cc3cccc(C(=O)O)c3OB2O)CC1
HCID178511528

未命名化合物

PRODUCTS

产物

1
反应SMILES：O=C(C[C@H]1CC[C@H](NCC2CCNCC2)CC1)N[C@H]1Cc2cccc(C(=O)O)c2OB1O
HCID178520740

未命名化合物

PROCEDURE

实验过程

Prepared from (R)-3-(2-(trans-4-aminocyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid (Example 6) and tert-butyl 4-formylpiperidine-1-carboxylate following the procedure in Example 27. Boc group was removed by treatment with 4N HCl in dioxane. The product was purified using reverse phase HPLC to afford the titled compound. ESI-MS m/z 444 (MH)+.

WORKUP

后处理

  1. customBoc group was removed by treatment with 4N HCl in dioxane
  2. customThe product was purified