Hydrochloric Acid → HCID 86722983, compound

HRID 1404377Notes

Reaction equation

C(OC([N:8]([CH2:47][CH2:48][NH:49]C(OC(C)(C)C)=O)[CH:9]1[CH2:12][CH:11]([CH2:13][C:14]([NH:16][C@H:17]([B:34]2[O:42][CH:41]3[C:36]([CH3:46])([CH:37]4[CH2:43][CH:39]([CH2:40]3)[C:38]4([CH3:45])[CH3:44])[O:35]2)[CH2:18][C:19]2[C:20]([O:32][CH3:33])=[C:21]([CH:29]=[CH:30][CH:31]=2)[C:22]([O:24]C(C)(C)C)=[O:23])=[O:15])[CH2:10]1)=O)(C)(C)C.Cl>>[NH2:49][CH2:48][CH2:47][NH:8][CH:9]1[CH2:12][CH:11]([CH2:13][C:14]([NH:16][C@H:17]([B:34]2[O:42][CH:41]3[C:36]([CH3:46])([CH:37]4[CH2:43][CH:39]([CH2:40]3)[C:38]4([CH3:45])[CH3:44])[O:35]2)[CH2:18][C:19]2[C:20]([O:32][CH3:33])=[C:21]([CH:29]=[CH:30][CH:31]=2)[C:22]([OH:24])=[O:23])=[O:15])[CH2:10]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86722984HCID 86722984, compound

Product 1

HCID 86722983HCID 86722983, compound

Procedure

Prepared from of tert-butyl 3-((R)-2-(2-(3-(tert-butoxycarbonyl(2-(tert-butoxycarbonylamino)ethyl)amino)cyclobutyl)acetamido)-2(2,9,9-trimethyl-3,5-dioxa-4-bora-tricyclo[6.1.1.02,6]dec-4-yl)ethyl)-2-methoxybenzoate (Step 4 of Example 55) and 4 N HCl following the procedure described in Step 1 of Example 53.

Sources & evidence

ORD record: ord-af893ea4ce224d1baf9452d41d4d3695
Source dataset: uspto-grants-2014_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08912169B2

Reaction notes

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