Trifluoroacetic acid → HCID 178520746, compound

HRID 1404381Notes

Reaction equation

HRID 1404381 reaction equation
[Si]([O:8][CH2:9][CH2:10][NH:11][CH2:12][CH2:13][NH:14][C@H:15]1[CH2:20][CH2:19][C@H:18]([CH2:21][C:22]([NH:24][C@H:25]2[CH2:30][C:29]3[CH:31]=[CH:32][CH:33]=[C:34]([C:35]([OH:37])=[O:36])[C:28]=3[O:27][B:26]2[OH:38])=[O:23])[CH2:17][CH2:16]1)(C(C)(C)C)(C)C.C(O)(C(F)(F)F)=O>O>[OH:38][B:26]1[C@@H:25]([NH:24][C:22](=[O:23])[CH2:21][C@H:18]2[CH2:19][CH2:20][C@H:15]([NH:14][CH2:13][CH2:12][NH:11][CH2:10][CH2:9][OH:8])[CH2:16][CH2:17]2)[CH2:30][C:29]2[CH:31]=[CH:32][CH:33]=[C:34]([C:35]([OH:37])=[O:36])[C:28]=2[O:27]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178455264HCID 178455264, compound

Product 1

HCID 178520746HCID 178520746, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To the compound from step 1 was added a mixture of TFA (2 mL) and H2O (0.2 mL). The resultant reaction mixture was stirred at RT for 2 hr. The solvents were then removed in vacuo and the residue purified by reverse phase preparative HPLC and dried using lyophilization. ESI-MS m/z 434 (MH)+.

Workup

  1. customThe resultant reaction mixture
  2. customThe solvents were then removed in vacuo
  3. customthe residue purified by reverse phase preparative HPLC
  4. customdried

Sources & evidence

ORD record
ord-aa620ac313ab4c18bb7cbbb12c6b5615
Source dataset
uspto-grants-2014_12
Patent number
US08912169B2

Reaction notes

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