Hydrochloric Acid → HCID 178462034, compound

HRID 1404383Notes

Reaction equation

HRID 1404383 reaction equation
C(OC([NH:8][C@@H:9]([CH3:39])[CH2:10][NH:11][CH2:12][CH2:13][NH:14][C@H:15]1[CH2:20][CH2:19][C@H:18]([CH2:21][C:22]([NH:24][C@H:25]2[CH2:30][C:29]3[CH:31]=[CH:32][CH:33]=[C:34]([C:35]([OH:37])=[O:36])[C:28]=3[O:27][B:26]2[OH:38])=[O:23])[CH2:17][CH2:16]1)=O)(C)(C)C.Cl>>[NH2:8][C@@H:9]([CH3:39])[CH2:10][NH:11][CH2:12][CH2:13][NH:14][C@H:15]1[CH2:20][CH2:19][C@H:18]([CH2:21][C:22]([NH:24][C@H:25]2[CH2:30][C:29]3[CH:31]=[CH:32][CH:33]=[C:34]([C:35]([OH:37])=[O:36])[C:28]=3[O:27][B:26]2[OH:38])=[O:23])[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178461770HCID 178461770, compound

Product 1

HCID 178462034HCID 178462034, compound

Procedure

To the compound from step 1 was added 3N HCl (2 ml) and the resultant reaction mixture was heated at reflux for 1 hr. The solvents were then removed in vacuo and the residue purified by reverse phase preparative HPLC and dried using lyophilization. ESI-MS m/z 447 (MH)+.

Workup

  1. customthe resultant reaction mixture
  2. temperaturewas heated
  3. temperatureat reflux for 1 hr
  4. customThe solvents were then removed in vacuo
  5. customthe residue purified by reverse phase preparative HPLC
  6. customdried

Sources & evidence

ORD record
ord-1efb0c513b3c4451b0901e6010d9b393
Source dataset
uspto-grants-2014_12
Patent number
US08912169B2

Reaction notes

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