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HRID1404393

反应详情

EQUATION

反应方程式

HRID 1404393 的结构方程式

REACTANTS

反应物

4
反应SMILES：CC(=O)O
HCID176

Acetic Acid

C2H4O2

反应SMILES：CC(C)=O
HCID180

Acetone

C3H6O

反应SMILES：CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

反应SMILES：NCCN[C@H]1CC[C@H](CC(=O)N[C@H]2Cc3cccc(C(=O)O)c3OB2O)CC1
HCID178511351

未命名化合物

PRODUCTS

产物

1
反应SMILES：CC(C)NCCN[C@H]1CC[C@H](CC(=O)N[C@H]2Cc3cccc(C(=O)O)c3OB2O)CC1
HCID178457401

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
反应SMILES：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To (R)-3-(2-(trans-4-(2-aminoethylamino)cyclohexyl)acetamido)-2-hydroxy-3,4-dihydro-2H-benzo[e][1,2]oxaborinine-8-carboxylic acid from Example 15 (92 mg) in MeOH (2 mL) was added TEA (70 μL), acetic acid (30 μL), acetone (0.1 mL) and sodium triacetoxyborohydride (212 mg). The reaction mixture was stirred overnight at RT. Solvent was removed and the product was purified using reverse phase HPLC to afford the titled compound. ESI-MS m/z 432 (MH)+.

WORKUP

后处理

  1. customSolvent was removed
  2. customthe product was purified