Hydrochloric Acid → HCID 178483798, compound

HRID 1404414Notes

Reaction equation

HRID 1404414 reaction equation
C(OC([N:8]([CH2:49][CH2:50][N:51]([CH3:53])[CH3:52])[C@H:9]1[CH2:14][CH2:13][C@H:12]([CH2:15][C:16]([NH:18][C@H:19]([B:36]2[O:44]C3C(C)(C4CC(C3)C4(C)C)O2)[CH2:20][C:21]2[C:22]([O:34]C)=[C:23]([CH:31]=[CH:32][CH:33]=2)[C:24]([O:26]C(C)(C)C)=[O:25])=[O:17])[CH2:11][CH2:10]1)=O)(C)(C)C.Cl>>[CH3:52][N:51]([CH3:53])[CH2:50][CH2:49][NH:8][C@H:9]1[CH2:14][CH2:13][C@H:12]([CH2:15][C:16]([NH:18][C@H:19]2[CH2:20][C:21]3[CH:33]=[CH:32][CH:31]=[C:23]([C:24]([OH:26])=[O:25])[C:22]=3[O:34][B:36]2[OH:44])=[O:17])[CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 178491872HCID 178491872, compound

Product 1

HCID 178483798HCID 178483798, compound

Procedure

To the compound from step 2 (40 mg) was added 3N HCl (2 ml) and the resultant reaction mixture was heated at reflux for 1 hr. The solvents were then removed in vacuo and the residue purified by reverse phase preparative HPLC and dried using lyophilization. ESI-MS m/z 418 (MH)+.

Workup

  1. customthe resultant reaction mixture
  2. temperaturewas heated
  3. temperatureat reflux for 1 hr
  4. customThe solvents were then removed in vacuo
  5. customthe residue purified by reverse phase preparative HPLC
  6. customdried

Sources & evidence

ORD record
ord-667b26f2da9949c5a1f3f68cab536fb8
Source dataset
uspto-grants-2014_12
Patent number
US08912169B2

Reaction notes

Loading…