Sulfuric Acid → 2-(Pyridin-4-yl)morpholine

HRID 1404430Notes

Reaction equation

HRID 1404430 reaction equation
O[CH2:2][CH2:3][NH:4][CH2:5][CH:6]([C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1)[OH:7].S(=O)(=O)(O)O>>[N:11]1[CH:12]=[CH:13][C:8]([CH:6]2[O:7][CH2:2][CH2:3][NH:4][CH2:5]2)=[CH:9][CH:10]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 67289794HCID 67289794, compound

Product 1

HCID 217504972-(Pyridin-4-yl)morpholine

Procedure

2-(Pyridin-4-yl)morpholine is prepared by treating 2-(2-hydroxyethylamino)-1-(pyridin-4-yl)ethanol with fuming sulfuric acid at 170° C. according to F. Zymalkowski and F. Koppe (Arch. Pharmaz. 1961, 294, 453-468).

Sources & evidence

ORD record
ord-794e170b452e443eb779609893f1ab9e
Source dataset
uspto-grants-2014_12
Patent number
US08912329B2

Reaction notes

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