反应详情

温度

-78 °C

To a 2 M lithium diisopropylamine solution in THF of −78° C. is added 5-benzylpyrrolidin-2-one and the mixture is stirred for 1.5 hours at −78° C. Then 1-propyl bromide is added and the reaction is stirred for another 1.5 hours at −78° C. The reaction mixture is allowed to warm up to 0° C. before ice-cold water with acetic acid is added and subsequently extracted 3 times with dichloromethane. The dichloromethane is concentrated in vacuo and the residue is dissolved in dichloromethane, washed with saturated NaHCO3 and brine. Crude 5-benzyl-3-propylpyrrolidin-2-one is obtained after removal of the solvents in vacuo. The product is purified by column chromatography.

1. stirringthe reaction is stirred for another 1.5 hours at −78° C
2. additionis added
3. extractionsubsequently extracted 3 times with dichloromethane
4. concentrationThe dichloromethane is concentrated in vacuo
5. dissolutionthe residue is dissolved in dichloromethane
6. washwashed with saturated NaHCO3 and brine