Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1404615생성일: 2026년 10월 26일
2,6-Dichloro-3-fluorobenzaldehyde → tert-butyl 4-[4-[1-[(E)-(2,6-dichloro-3-fluorophenyl)methylideneamino]pyrrolo[3,2-b]pyridin-6-yl]pyrazol-1-yl]piperidine-1-carboxylate
https://huagongshe.com/reaction/1404615
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2,6-Dichloro-3-fluorobenzaldehyde | HCID 18945674 | — |
| 반응물 | tert-butyl 4-[4-(1-amino-1H-pyrrolo[3,2-b]pyridin-6-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate | HCID 58532283 | — |
| 용매 | Heptane | HCID 8900 | — |
| 생성물 | tert-butyl 4-[4-[1-[(E)-(2,6-dichloro-3-fluorophenyl)methylideneamino]pyrrolo[3,2-b]pyridin-6-yl]pyrazol-1-yl]piperidine-1-carboxylate | HCID 87408523 | 87% |
반응 단계
A mixture of tert-butyl 4-[4-(1-amino-1H-pyrrolo[3,2-b]pyridin-6-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate (100 mg, 0.26 mmol) and 2,6-dichloro-3-fluorobenzaldehyde (50 mg, 0.26 mmol) in heptane (2.0 mL) was heated in a sealed tube at 120° C. for 15 min. The product was purified by column chromatography (ethyl acetate) to give the desired intermediate as an off-white solid (126 mg, yield 87%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08912330B2 |
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| 출처 데이터셋 | uspto-grants-2014_12 |
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| ORD ID | ord-355977874143463c8fea52faafc1cbe5 |
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| 출처 메모 | uspto-grants-2014_12 |
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