2-Pyridinecarboxaldehyde → HCID 178419322, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-bromo-1,2-diaminobenzene (1.00 g, 5.35 mmol), sodium bisulfite (1.02 g) in water (8 mL) and ethanol (80 mL) and 2-pyridine carboxaldehyde (0.63 g, 5.88 mmol) was heated at 90° C. for 15 h. The reaction was cooled to room temperature and concentrated under vacuum. The residue was partitioned between water (60 mL) and chloroform (80 mL) and the aqueous phase was extracted with chloroform (2×50 mL). The organic extracts were combined, dried (MgSO4), filtered and concentrated under vacuum to give the crude product (1.36 g). The residue was purified by column chromatography eluting with EtOAc:hexaxes 0 to 50% to afford 594 mg of 5-bromo-2-(pyridin-2-yl)-1H-benzo[d]imidazole (40%).

Provenance & Evidence