HCID 11514112, compound → Triethylenetetramine

HRID 1404761Notes

Reaction equation

HRID 1404761 reaction equation
[C:1]([CH2:3][N:4]1[CH2:8][CH2:7][N:6]([CH2:9][C:10]#[N:11])C1C1C=CC=CC=1)#[N:2].NCCN1CCN(CCN)C1C1C=CC=CC=1>>[NH2:2][CH2:1][CH2:3][NH:4][CH2:8][CH2:7][NH:6][CH2:9][CH2:10][NH2:11]

Participants

3

Reactant 2

HCID 11514112HCID 11514112, compoundHCID 11715620HCID 11715620, compound2×

Product 1

HCID 5565Triethylenetetramine

Procedure

This Example demonstrates the reduction of (3-cyanomethyl-2-phenyl-imidazolidin-1-yl)-acetonitrile (5) to intermediate 2-[3-(2-Amino-ethyl)-2-phenyl-imidazolidin-1-yl]-ethylamine (8). As shown in Scheme 9, intermediate (8) is treated with an acid to form a triethylenetetramine salt. The reduction is effected by LiAlH4, the acid used is hydrochloric acid and the tetrahydrochloride salt of triethylenetetramine is produced.

Workup

  1. additionis treated with an acid

Sources & evidence

ORD record
ord-f54e3b5b6fb74c66bd291bcbef11c113
Source dataset
uspto-grants-2014_12
Patent number
US08912362B2

Reaction notes

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