Ammonium Hydroxide → Morphine

HRID 1404844Notes

Reaction equation

HRID 1404844 reaction equation
S(O)(O)(=O)=O.[CH:6]1[C:22]2[CH2:21][C@H:20]3[N:23]([CH2:25][CH2:26][C@@:12]45[C@H:19]3[CH:18]=[CH:17][C@H:15]([OH:16])[C@@H:13]4[O:14][C:10]([C:11]=25)=[C:8]([OH:9])[CH:7]=1)[CH3:24].[NH4+].[OH-]>O>[CH:6]1[C:22]2[CH2:21][C@H:20]3[N:23]([CH2:25][CH2:26][C@@:12]45[C@H:19]3[CH:18]=[CH:17][C@H:15]([OH:16])[C@@H:13]4[O:14][C:10]([C:11]=25)=[C:8]([OH:9])[CH:7]=1)[CH3:24]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 546428064-31-3

Product 1

HCID 5288826Morphine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Morphine base (FIG. 8A) was synthesized from the commercial sulfate salt of this opiate substance (Sigma-Aldrich), according to a classical chemical procedure reported in 1972 by E. J. Simon (E. J. Simon et al., Proc. Natl. Acad. Sci. USA, 69: 1835-1837, 1972). This reaction was carried out as follows; 64 mg of morphine sulfate/ml were dissolved in distilled water at room temperature under constant stirring. The pH of this solution was adjusted at 8.0 with NH4OH. The morphine base was subsequently crystallized through precipitation at pH 8, filtered and dried through evaporation at 60° C. under vacuum conditions.

Workup

  1. customThe morphine base was subsequently crystallized through precipitation at pH 8
  2. filtrationfiltered
  3. customdried through evaporation at 60° C. under vacuum conditions

Sources & evidence

ORD record
ord-b37b47b8ccfc4abbb004e44546459b09
Source dataset
uspto-grants-2014_12
Patent number
US08916170B2

Reaction notes

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